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Very Overweight

A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight

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Study Purpose

The main purpose is to learn more about how tirzepatide affects body weight in participants with overweight and obesity.

Time Commitment

The study has two phases: A main phase and an extension phase. The main phase of the study will last 72 weeks (14 visits). Participants with prediabetes will continue in the extension for another 2 years

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria


Male Female


18+ years

-Patients must have body mass Index (BMI) ≥30 kilograms per square meter (kg/m²), or ≥27 kg/m² and previous diagnosis with at least one of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease

-Patients must have history of at least one unsuccessful dietary effort to lose body weight

-Patients must not have Diabetes mellitus

-Patients must not have change in body weight greater than 5 kg within 3 months prior to starting study

-Patients must not have obesity induced by other endocrinologic disorders or monogenetic or syndromic forms of obesity

-Patients must not have history of pancreatitis

-Patients must not have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)

-Patients must not have history of significant active or unstable major depressive disorder (MDD) or other severe psychiatric disorder within the last 2 years

-Patients must not have any lifetime history of a suicide attempt

Where to Participate

Where to Participate

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