Study Condition(s): Type 2 Diabetes

A Study of LY3298176 in Participants With Type 2 Diabetes (T2DM)

Study Alias: GPGA

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT02759107 {{ currentLocaleObject.registryAnchorText }}

Withdrawn Active, not recruiting

Study Purpose

The 3 main purposes of this study are to determine the safety of LY3298176 and any side effects that might be associated with it, how much LY3298176 gets into the bloodstream and how long it takes the body to get rid of it and how LY3298176 affects the levels of blood sugar. Each participant will enroll in only one part. This study is for research purposes only, and is not intended to treat any medical condition.

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria


Male Female


21 years
70 years

Time Commitment

Your participation in part C could last approximately 12-14 weeks and include approximately 12 visits to the study center.
  • Participant must be diagnosed with T2DM at least 1 year before enrollment for Part C
  • Participant with T2DM (Part C only) must have T2DM controlled with diet and exercise alone or are stable on a single oral antidiabetic medication (metformin for at least 30 days or sulfonylureas. Participants receiving sulfonylureas may participate only if this treatment is stopped for at least 6 weeks before dosing with study drug
  • Participant must not have a history or presence of pancreatitis (history of chronic pancreatitis or idiopathic acute pancreatitis)
  • Participant with T2DM (Part C only) must not have had more than 1 episode of severe low blood sugar within 6 months before entry into the study or has a history of being unaware or poorly recognizing symptoms of low blood sugar
  • Participant in Part C must not have known allergies to LY3298176, GLP-1 analogs, or related compounds, or acetaminophen

Where to Participate

2 locations are currently available of 2 planned
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