Study Condition(s): Terminal Illness

A 18F-AV-1451 Autopsy Study

Study Alias: 1451

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT02516046 {{ currentLocaleObject.registryAnchorText }}

Completed Completed

Study Purpose

The purpose of this study is to test the relationship between ante-mortem 18F-AV-1451 Positron Emission Tomography (PET) imaging and tau neurofibrillary pathology associated with Alzheimer's disease (AD), as measured at autopsy.

Completed Study

The results of this study are not yet available.

Who Participated? Tool Tip Icon

Here you can find out a bit more about the requirements for volunteers who took part in this study


Male Female


50+ years

Time Commitment

Your participation in the study could last up to nine months and will include one visit to the PET imaging center.
  • Participant must have a projected life expectancy of ≤ 6 months
  • Participant must be able to tolerate a 20 minute Positron Emission Tomography (PET) scan
  • Participant must give informed consent or have a legally authorized representative to consent for study procedures and brain donation consistent with the legal requirements of the State in which they die
  • Participant must not be undergoing aggressive treatment with life sustaining measures
  • Participant must not have a known structural brain lesion that would interfere either with PET imaging or pathological assessment
  • Participant must not be currently receiving any investigational medications except with permission from the study sponsor
  • Participant must not have previously participated in an experimental study with an amyloid or tau targeting agent
  • Participant must not have a suspected disorder of the brain due to alcoholism or end-stage liver disease
  • Female participant must not be of childbearing potential

Where This Study Took Place Tool Tip Icon

33 locations participated
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