Study Condition(s): Stomach Cancer, Gastroesophageal Junction Cancer (GEJ)

A Study of Ramucirumab (LY3009806) in Combination With Paclitaxel in Participants With Gastric Cancer

Study Alias: JVCZ

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT02514551 {{ currentLocaleObject.registryAnchorText }}

Study Purpose

The main purpose of this study is to evaluate the efficacy of an alternative dose of ramucirumab in combination with paclitaxel in participants with second-line metastatic or locally advanced, unresectable gastric or gastroesophageal junction adenocarcinoma (GEJ).

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria

Gender

Male Female

Age

18+ years

Time Commitment

You can participate in this study for as long as your study doctor determines that you are benefiting from the study treatment.
  • Participant must have a diagnosis of Gastric Cancer (gastric or gastroesophageal junction adenocarcinoma (GEJ) adenocarcinoma)

  • Participant must have disease progression during or within 4 months after last dose of first-line chemotherapy

  • Participant must have received combination chemotherapy

  • Male participants must be sterile or agree to use a reliable method of birth control

  • Female participants of child-bearing potential must have a negative pregnancy test and agree to use a highly effective method of birth control; all other female participants must be surgically sterile or postmenopausal

  • Participant must not have known brain metastases or leptomeningeal disease

  • Participant must not have a history of gastrointestinal perforation or fistula within 6 months

  • Participant must not have a history of inflammatory bowel disease or Crohn's disease requiring medical intervention within 12 months

  • Participant must not have Child-pugh B, C cirrhosis or HIV

Where to Participate

43 locations are currently available of 50 planned
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