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Solid Tumor, Lung Cancer

A Study of Anti-PD-L1 Checkpoint Antibody (LY3300054) Alone and in Combination in Participants With Advanced Refractory Solid Tumors (PACT)

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Study Purpose

The main purpose of this study is to evaluate the safety and tolerability of anti-programmed cell death ligand 1 (PD-L1) checkpoint antibody LY3300054 in participants with advanced refractory solid tumors.

Time Commitment

The duration of your participation will depend on the duration of your study treatment, your disease progression, and follow-up visits

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria


Male Female


18+ years
  • Participant must have diagnosis of advanced solid tumor confirmed by histology or cytology
  • Participants entering the Phase 1a dose escalation must submit, if available, an archival tumor tissue sample
  • Participants participating ONLY in the Phase 1b expansion must submit tissue sample from either a newly obtained core or excisional biopsy of a tumor lesion or a recent (≤3 years since last documented progression of disease.) biopsy
  • Participant must not have a serious concomitant systemic disorder including HIV, active hepatitis B virus (HBV), active hepatitis C virus (HCV), active autoimmune disorder or disease requiring high dose of steroids
  • Participant must not have a bowel obstruction or chronic diarrhea
  • Participant must not have symptomatic or uncontrolled brain metastases, spinal cord compression, or leptomeningeal disease requiring concurrent treatment
  • Participant must not have received a live vaccine within 30 days before the first dose of study treatment

Where to Participate

Where to Participate

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