Study Condition(s): Solid Tumor

A Study of LY2510924 and Durvalumab in Participants With Solid Tumors

Study Alias: CXAD

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT02737072 {{ currentLocaleObject.registryAnchorText }}

Study Purpose

The main purpose of this study is to evaluate the safety and tolerability of chemokine (C-X-C Motif) receptor 4 (CXCR4) peptide antagonist LY2510924 and durvalumab for phase 1a and 1b in participants with advanced refractory solid tumors.

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria

Gender

Male Female

Age

18+ years

Time Commitment

The duration of your participation depends on how well your disease responds to the study treatment.
  • Participant must have confirmation of advanced solid tumor by histology or cytology
  • Participant must provide tissue from a newly obtained core or excisional biopsy of a tumor lesion or from a recent biopsy ≤3 years since last documented progression of disease
  • Participant must not have a serious concomitant systemic disorder including HIV, active hepatitis B virus (HBV), active hepatitis C virus (HCV), active autoimmune disorder or disease requiring high dose of steroids
  • Participant must not have a bowel obstruction, history or presence of intestinal disease, extensive intestinal resection or chronic diarrhea
  • Participant must not have had prior therapy with an anti-programmed cell death 1 (PD-1), anti-PD-L1, anti-PD-L2, or anticytotoxic T lymphocyte-associated antigen-4 antibody
  • Participant must not have symptomatic or uncontrolled brain metastases, spinal cord compression, or leptomeningeal disease requiring treatment while in the trial
  • Participant must not have received a live vaccine within 30 days before the first dose of study treatment test

Where to Participate

1 locations are currently available of 5 planned
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