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Active, not recruiting

Soft Tissue Sarcoma

A Study of Olaratumab (LY3012207) in Participants With Advanced Soft Tissue Sarcoma (ANNOUNCE-2)

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Study Purpose

The main purpose of this study is to evaluate the safety and efficacy of two anti-cancer drugs (gemcitabine and docetaxel) with and without the study drug known as olaratumab in participants with advanced soft tissue sarcoma (STS) or STS that has spread to another part(s) of the body.

Time Commitment

Your participation could last >12 months depending on how you and your tumor respond.

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria


Male Female


16+ years
  • Participant must have completed all previous therapies more than 3 weeks before the first dose of study drug

  • Participant must be willing to provide tumor tissue

  • Participant must not be diagnosed with gastrointestinal stromal tumor (GIST) or Kaposi sarcoma

  • Participant must not have active central nervous system or brain metastasis at the start of the study

  • Participant must not have received prior treatment with gemcitabine or docetaxel (this includes participants previously enrolled in I5B-MC-JGDJ (NCT02451943)

  • Participant must not have planned elective surgery or will require surgery during study participation

  • Female participant must not be pregnant or breastfeeding

  • Participant must not have active fungal, bacterial, and/or known viral infection including HIV or viral (A, B, or C) hepatitis

Where to Participate

Where to Participate

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