Study Purpose

This study is known as a "drug interaction study." The purpose is to learn how commonly used drugs or substances (midazolam, warfarin, dextromethorphan, omeprazole, and caffeine) and their breakdown products get into the bloodstream after taking a "cocktail" (combination) of them before and after multiple doses of mirikizumab.

  The study will last about 23 weeks for each participant. Screening must be completed within 4
  weeks prior to study start.

Completed Study

The results of this study are not yet available.

Time Commitment

The study will last about 23 weeks for each participant, which includes 10 outpatient visits and 2 inpatient visits (with 3 overnights per visit).

Who Participated? Tool Tip Icon

Here you can find out a bit more about the requirements for volunteers who took part in this study


Male Female


18+ years
  • Participants must have chronic plaque psoriasis for at least 6 months and are candidates for treatment with a prescription drug or light therapy
  • Participants must have moderate to severe plaque psoriasis, as determined by the investigator
  • Participants must not be pregnant or nursing (breastfeeding)
  • Participants must not have a history of an ongoing, chronic or recurrent infection, or evidence of tuberculosis
  • Participants must not have had major surgery within 8 weeks prior to first admission to the clinical site or during the study
  • Participants must not have a history of lymphoma (cancer of the lymph nodes), leukemia (blood cancer), or any other cancer
  • Participants must not require treatment with any drug given during the study. These include midazolam (sedative), warfarin (blood thinner), dextromethorphan (cough suppressant), omeprazole (stomach acid reducer) and caffeine
  • Participants must not have participated in any other research study with the study drug known as mirikizumab

Where This Study Took Place Tool Tip Icon

Where This Study Took Place Tool Tip Icon

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