Study Condition(s): Parkinson's Disease Dementia

A Study of LY3154207 in Participants With Parkinson's Disease Dementia (PRESENCE)

Study Alias: HBEH

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT03305809 {{ currentLocaleObject.registryAnchorText }}

Withdrawn Not yet recruiting

Study Purpose

The purpose of this study is to evaluate the safety and efficacy of three doses of study drug LY3154207 in participants with mild-to-moderate Parkinson's disease dementia.

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria

Gender

Male Female

Age

40 years
85 years

Time Commitment

Your participation could last approximately 18 weeks and include 12 visits to the study center.
  • Participant must have Parkinson's Disease with symptoms for at least 2 years
  • Participant must have dementia
  • Participants on anti-parkinsonian agents, must be on stable doses for at least 4 weeks prior to entering study
  • Participants on antidepressant medications, must be on stable doses for at least 8 weeks prior to entering study
  • Participants on blood pressure lowering medications, must be on stable doses for at least 3 months prior to entering study
  • Male participant must use appropriate contraception. Female participant must not be of childbearing potential
  • Participant must have a reliable caregiver who is in frequent contact with participant and will accompany participant to select visits
  • Participant must not have a history of stroke in the last 6 months
  • Participant must not have a current or any previous diagnosis of bipolar disorder, schizophrenia, or other primary psychotic disorder
  • Participant must not have a history of substance abuse within the past 1 year, and/or substance dependence within the past 1 year, not including caffeine and nicotine

Where to Participate

72 locations are currently available of 73 planned
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