Study Condition(s): Pancreatic Cancer

A Study of Galunisertib (LY2157299) and Durvalumab (MEDI4736) in Participants With Metastatic Pancreatic Cancer

Study Alias: JBEG

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT02734160 {{ currentLocaleObject.registryAnchorText }}

Study Purpose

The main purpose of this study is to evaluate the safety and efficacy of the study drug known as galunisertib administered in combination with the anti-programmed cell death-ligand 1 (PD-L1) antibody, durvalumab, in participants with refractory metastatic pancreatic cancer.

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria

Gender

Male Female

Age

18+ years

Time Commitment

The duration of your participation depends on how well your disease responds to the study treatment.
  • Participants must have metastatic pancreatic cancer, confirmed by histology or cystology. Recurrence must be documented by diagnostic biopsy.

  • Participants must have had disease progression, been resistant, or intolerant to no more than 2 prior systemic regiments for locally advanced or metastatic pancreatic cancer.

  • Participants who have received prior neoadjuvant therapy and who now have metastatic disease must have received 1 of the following treatments for their metastatic disease: FOLFIRINOX, nanoparticle albumin-bound paclitaxel/gemcitabine, TS-1 (tegafur gimeracil oteracil potassium), irinotecan liposome injection/5-fluorouracil (5FU)/Leucovorin or single-agent gemcitabine prior to entering the study

  • For some parts of the study, participants must be willing to undergo a tumor biopsy or to provide an available archival tumor sample

  • Participants must use approved contraceptive methods

  • Participants must not have moderate or severe cardiovascular disease

Where to Participate

13 locations are currently available of 15 planned
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