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Completed

Nonradiographic Axial Spondyloarthritis

A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis (COAST-X)

RHBX | {{ defaultRegistry.registryAnchorText }} NCT02757352 {{ currentLocaleObject.registryAnchorText }}

Study Purpose

The main purpose of this study is to evaluate the safety and efficacy of the study drug known as ixekizumab in biologic disease modifying antirheumatic drug (bDMARD) naïve participants with nonradiographic axial spondyloarthritis (nonrad-axSpA).

Completed Study

The results of this study are not yet available.

Time Commitment

Your participation could last up to 1 ½ years and include 15 visits to the study center. After this study, you may be eligible to enter another study that could last up to 2 more years.

Who Participated? Tool Tip Icon

Here you can find out a bit more about the requirements for volunteers who took part in this study

Gender

Male Female

Age

18+ years
  • Participant must have diagnosis of nonradiographic axial spondyloarthritis (nr-axSpA)

  • Participant must be able to walk

  • Participant must have a history of back pain for ≥3 months that started before 45 years of age

  • Participants must have had an inadequate response to at least 2 non-steroidal anti-inflammatory drugs (NSAIDS) for duration of 4 weeks or cannot tolerate NSAIDS.

  • Participants that are taking NSAIDS must be on a stable dose for at least 2 weeks prior to randomization

  • Participants must have a history of prior therapy for axSpA for at least 12 weeks prior to screening for the study

  • Participants must not have radiographic sacroiliitis

  • Participants must not have received any prior, or are currently receiving treatment with biologics, tumor necrosis factor inhibitors or other immunomodulatory agents

  • Female participants must not be pregnant or breastfeeding

Where This Study Took Place Tool Tip Icon

Where This Study Took Place Tool Tip Icon

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