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Active, not recruiting

Non-small Cell Lung Cancer

A Study of Ramucirumab (LY3009806) or Necitumumab (LY3012211) Plus Osimertinib in Participants With Lung Cancer

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Study Purpose

The main purpose of this study is to evaluate the safety of ramucirumab or necitumumab in combination with osimertinib in participants with non-small cell lung cancer (NSCLC).

Time Commitment

The duration of your participation will depend on the duration of your study treatment, your disease progression, and follow-up visits

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria


Male Female


18+ years
  • Participant must have a diagnosis of NSCLC with at least 1 measurable lesion
  • Participant must not have had previous treatment with osimertinib or third generation EGFR TKIs
  • Participant must not have experienced a heart attack, unstable angina, or stroke, within 6 months prior to enrollment
  • Participant must not have a history of deep vein thrombosis, pulmonary embolism, or any other significant venous thromboembolism during the 3 months prior to study enrollment
  • Participant must not have a bowel obstruction, Crohn's disease, ulcerative colitis, chronic diarrhea or a history of gastrointestinal perforation and/or fistula within 6 months prior to enrollment
  • Participant must not have uncontrolled hypertension
  • Participant must not be receiving concurrent treatment with other anticancer therapy, including other chemotherapy, immunotherapy, hormonal therapy, chemoembolization, or targeted therapy or radiotherapy treatment to more than 30% of the bone marrow or with a wide field of radiation within 4 weeks prior to enrollment

Where to Participate

Where to Participate

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