Study Condition(s): Non-small Cell Lung Cancer, Breast Cancer

A Study of Abemaciclib (LY2835219) in Participants With Non-Small Cell Lung Cancer or Breast Cancer

Study Alias: JPCE

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT02779751 {{ currentLocaleObject.registryAnchorText }}

Study Purpose

The main purpose of this study is to evaluate the safety and efficacy of abemaciclib in combination with pembrolizumab in participants with advanced non-small cell lung cancer (NSCLC) or hormone receptor positive (HR+), human epidermal growth factor receptor negative (HER2-) breast cancer.

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria

Gender

Male Female

Age

18+ years

Time Commitment

Your participation could last up to 6 months depending on how you and your tumor respond.
  • Participant must have a Stage IV diagnosis of one of the following:
    • KRAS mt, PD-L1+ NSCLC
    • squamous NSCLC or
    • HR+, HER2- Metastatic breast cancer
  • Participant must be willing and able to provide tumor tissue both prior to treatment and after treatment initiation
  • Participant must have discontinued all previous treatments for cancer and recovered from the acute effects of therapy
  • Participant must not have a history of interstitial lung disease or pneumonitis
  • Participant must not have a history of or active autoimmune disease, or other syndrome that requires systemic steroids or autoimmune agents for the past 2 years
  • Participant must not have received a live vaccination within 30 days of study start
  • Participant must not have received prior treatment with an anti PD-1, anti-programmed death ligand 1 (PD-L1), or anti cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) agent

Where to Participate

31 locations are currently available of 31 planned
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