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Non-small Cell Lung Cancer

A Study of the Combination of Necitumumab (LY3012211) and Pembrolizumab (MK3475) in Participants With NSCLC

JFCQ | {{ defaultRegistry.registryAnchorText }} NCT02451930 {{ currentLocaleObject.registryAnchorText }}

Study Purpose

The main purpose of this study is to evaluate the safety and efficacy of the combination of necitumumab with pembrolizumab in participants with stage IV NSCLC.

Completed Study

The results of this study are not yet available.

Time Commitment

The duration of your participation will depend on the duration of your study treatment, your disease progression, and follow-up visits

Who Participated? Tool Tip Icon

Here you can find out a bit more about the requirements for volunteers who took part in this study


Male Female


18+ years
  • Participant must have stage IV Non-Small Cell Lung Cancer

  • Participant must have progressed after 1 platinum-based chemotherapy regimen. Participant whose tumor has an EGFR activating mutation or ALK translocations must have prior treatment with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and anaplastic lymphoma kinase (ALK) inhibitors

  • Participant must have tumor tissue available for biomarker analyses

  • Participant must not have surgery within 30 days of study start

  • Participant must not have had prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-cytotoxic T lymphocyte-associated antigen-4 antibody or EGFR-directed monoclonal antibody (mAb)

  • Participant must not have undergone chest irradiation within 4 weeks prior to receiving study treatment

  • Participant must not be currently enrolled in a clinical trial involving an investigational product or non-approved use of a drug or device

  • Participant must not be pregnant or breastfeeding

Where This Study Took Place Tool Tip Icon

Where This Study Took Place Tool Tip Icon

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