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Terminated

Liver Disease

A Study of Baricitinib (LY3009104) in Participants With Primary Biliary Cholangitis Who do Not Respond or Cannot Take UDCA

JAIV | {{ defaultRegistry.registryAnchorText }} NCT03742973 {{ currentLocaleObject.registryAnchorText }}

Study Purpose

This study evaluates the safety and efficacy of baricitinib in participants with primary biliary cholangitis (PBC) who do not respond or are unable to take ursodeoxycholic acid (UDCA).

Terminated Study

This trial stopped recruiting or enrolling participants prematurely and will not start again. We are no longer examining or treating participants. The trial may have been stopped for many reasons. You may contact Lilly for further information.

Time Commitment

The study will last about 16 weeks and may include up to 7 visits.

Who Participated? Tool Tip Icon

Here you can find out a bit more about the requirements for volunteers who took part in this study

Gender

Male Female

Age

18+ years
  • Participants must have a diagnosis of PBC

  • Participants must be taking UDCA in a stable dose or have previously taken, but are intolerant

  • Participants must not have other liver diseases including:

    • Hepatitis C virus (HCV)
    • Hepatitis B virus (HBV) infection
    • Primary sclerosing cholangitis
    • Alcoholic liver disease
    • Autoimmune liver disease other than PBC, such as overlap hepatitis
    • Nonalcoholic steatohepatitis
    • Gilbert’s syndrome

  • Participants must not have a history of VTE (deep vein thrombosis/pulmonary embolism [DVT/PE])

  • Participants must not have a current or recent clinically serious infection

  • Participants must not are receiving unstable treatment for pruritus

  • Participants must not have received obeticholic acid

  • Participants must not have received fenofibrate or other fibrates for the treatment of PBC

Where This Study Took Place Tool Tip Icon

Where This Study Took Place Tool Tip Icon

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