Study Condition(s): Breast Cancer

A Neoadjuvant Study of Abemaciclib (LY2835219) in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast Cancer (neoMONARCH)

Study Alias: JPBY

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT02441946 {{ currentLocaleObject.registryAnchorText }}

Study Purpose

The purpose of this study is to evaluate the biological effects of abemaciclib in combination with anastrozole and compare those to the effects of abemaciclib alone and anastrozole alone in the tumors of postmenopausal women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 (HER2) negative breast cancer.

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria

Gender

Female

Age

18+ years

Time Commitment

Your participation could last up to 10 months depending on how you and your tumor respond.
  • Participant must have a diagnosis of HR+, HER2- breast cancer

  • Participant must be postmenopausal

  • Participant must not have bilateral invasive breast cancer or inflammatory breast cancer

  • Participant must not have metastatic breast cancer (local spread to axillary lymph nodes is permitted)

  • Participant must not have prior systemic therapy or radiotherapy for invasive or non-invasive breast cancer in the same breast as currently being treated

  • Participant must not have prior radiotherapy to the ipsilateral chest wall for any malignancy

  • Participant must not have prior anti-estrogen therapy

Where to Participate

70 locations are currently available of 75 planned
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