Study Condition(s): Melanoma, Breast Cancer, Brain Cancer, Non-small Cell Lung Cancer

A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer, Non-small Cell Lung Cancer, or Melanoma that has Spread to the Brain

Study Alias: JPBO

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT02308020 {{ currentLocaleObject.registryAnchorText }}

Study Purpose

The main purpose of this study is to evaluate the safety and effectiveness of the study drug known as abemaciclib in participants with hormone receptor positive breast cancer, non-small cell lung cancer (NSCLC), or melanoma that has spread to the brain.

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria

Gender

Male Female

Age

18+ years

Time Commitment

Your participation could last approximately 5 months depending on how you and your tumor respond.
  • Participant must have brain metastases secondary to HER2+ or HER2- breast cancer, NSCLC, or melanoma

  • Participant must have a life expectancy ≥12 weeks

  • Participant must not be taking concurrent enzyme-inducing antiepileptic drugs (EIAED)

  • Participant must not have had >2 seizures within 4 weeks prior to study entry

  • Participant must not have previously received treatment with any cyclin dependent kinase 6 (CDK6) inhibitor

Where to Participate

51 locations are currently available of 51 planned
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