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Axial Spondyloarthritis (Ankylosing Spondylitis)

A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis (COAST-W)

RHBW | {{ defaultRegistry.registryAnchorText }} NCT02696798 {{ currentLocaleObject.registryAnchorText }}

Study Purpose

The main purpose of this study is to evaluate the efficacy and safety of ixekizumab in participants with radiographic axial spondyloarthritis (rad-axSpA) who have taken tumor necrosis factor (TNF) inhibitor.

Time Commitment

Your participation could last up to 1.5 years and include 15 visits to the study center. After this study, you may be eligible to enter another study that could last up to 2 more years.

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria


Male Female


18+ years
  • Participant must be diagnosed with radiographic axial spondyloarthritis (rad-xSpA) with inflammation of the sacroiliac joint or region

  • Participant must be able to walk

  • Participant must have a history of back pain greater than or equal to 3 months which began at age 45 or younger

  • Participants must have a history of prior therapy for axSpA of at least 12 weeks prior to starting the study. Examples of prior therapy may include but are not limited to physical therapy, NSAID, and TNF inhibitor treatment

  • Participant must have had prior treatment with at least 1 but no more than 2 TNF inhibitors

  • Participant must not received a live vaccine within 12 weeks or received a vaccine with Bacillus Calmette-Guerin (BCG) within the past year

  • Participant must not have had major surgery within 8 weeks of baseline and will not require surgery during the study

  • Female participant must not be pregnant or breastfeeding

Where to Participate

Where to Participate

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