Study Condition(s): At Risk For Alzheimer's Disease

A Study of Solanezumab in Older Participants Who May be at Risk for Memory Loss (A4)

Study Alias: LZAZ

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT02008357 {{ currentLocaleObject.registryAnchorText }}

Recruiting Recruiting

Study Purpose

The purpose of this study is to test whether an investigational drug called solanezumab can slow the progression of memory problems associated with brain amyloid (protein that forms plaques in the brains of people with Alzheimer Disease [AD]).

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria

Gender

Male Female

Age

65 years
85 years

Time Commitment

Your participation could last approximately 3 years and include 48 visits to the study center
  • Participant must have a study partner that is willing to participate as a source of information and has at least weekly contact with the participant (contact can be in-person, via telephone or electronic communication)

  • Participant must not be receiving a prescription acetylcholinesterase inhibitor (AChEI) and/or memantine

  • Participant must have good vein access, such that intravenous drug delivery or multiple blood draws would be obtainable

  • Participant must not have a history within the last 5 years of a serious infectious disease affecting the brain (including neurosyphilis, meningitis, or encephalitis) or head trauma resulting in longer than expected loss of consciousness

  • Participant must not have a history within the last 5 years of cancer (with the exception of resected cutaneous squamous cell carcinoma in situ, basal cell carcinoma, cervical carcinoma in situ, or in situ prostate cancer)

  • Participant must not have a history within the past 2 years of major depression or bipolar disorder

  • Participant must not have a history within the past 5 years of chronic alcohol or drug abuse/dependence

  • Participant must not have a known history of human immunodeficiency virus (HIV)

Where to Participate

68 locations are currently available of 68 planned
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