Study Condition(s): Mild Cognitive Impairment, Mild Alzheimer's, Early Symptoms of Alzheimer's Disease, Moderate Alzheimer's

A Study of LY3372993 in Healthy Participants and Participants With Alzheimer's Disease (AD)

Study Alias: LAKA

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT03720548 {{ currentLocaleObject.registryAnchorText }}

Withdrawn Not yet recruiting

Study Purpose

The main purpose of this study is to evaluate the safety and tolerability of LY3372993 in healthy participants and participants with AD. The study will also investigate how much LY3372993 gets into the bloodstream and test the effects of LY3372993 in participants with AD. The study has two parts: Part A - Healthy participants will receive LY3372993 or placebo. Part A will last up to 17 weeks and Part B - Participants with AD will receive LY3372993 or placebo. Part B will last about 317 days.

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria

Gender

Male Female

Age

18 years
85 years

Time Commitment

Part A will last up to 17 weeks and may include up to 14 visits. Part B will last up to 317 days and may include 16 visits.
  • (Part A): Participants must be men or women in good health, between the ages of 18-45 (inclusive).
  • (Part A): Participants must not have memory or thinking problems or a family history of early onset AD.
  • (Part A): Male participants must agree to use birth control throughout the study and for 3 months after the last dose of the study drug. Female participants must not be able to bear children.
  • (Part B): Participants must be men or women, ages 55-85 (inclusive), with mild cognitive impairment or mild-moderate dementia due to Alzheimer’s disease.
  • (Part B): Participants must have a positive florbetapir scan and must be able to participate in MRI scans.
  • (Part B): Male participants must agree to use birth control throughout the study and for 3 months after the last dose of the study drug. Female participants must not be able to bear children.
  • (Part B): Participants must not be allergic to a common type of allergy medicine (antihistamines), epinephrine, or corticosteroids.”
  • (Part B): Participants must not have any significant medical or neurological illnesses that could affect the study results.
  • (Part B): Participants must have a study partner who can provide health information related to the study about the participant throughout the study.

Where to Participate

5 locations are currently available of 10 planned
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