Study Condition(s): Adult Type 2 Diabetes

A Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participants With Type 2 Diabetes and Increased Cardiovascular Risk

Study Alias: GPGM

Study Identifier(s): Tool Tip Icon {{ defaultRegistry.registryAnchorText }} NCT03730662 {{ currentLocaleObject.registryAnchorText }}

Recruiting Recruiting

Study Purpose

The purpose of the trial is to assess the efficacy and safety of tirzepatide taken once a week to insulin glargine taken once daily in participants with type 2 diabetes and increased cardiovascular risk.

Key Participation Requirements Tool Tip Icon

All clinical trials have rules about who can participate. This section outlines some of those rules. Please contact a study center to discuss the full set of criteria


Male Female


18+ years

Time Commitment

The study will last about 108 weeks and may include up to 30 visits.

-Participant must have type 2 diabetes mellitus (T2DM)

-Participant must be on stable treatment dose of at least 1 and no more than 3 oral antihyperglycemic drugs

-Participant must have increased risk for cardiovascular events

-Participant must be of stable weight

-Participant must not have T1DM

-Participant must not have pancreatitis

-Participant must not have disorders with slowed emptying of the stomach contents, or have had any stomach surgeries for the purpose of weight loss

-Participant must not have acute or chronic hepatitis or symptoms of any other liver disease

-Participant must not have had a heart attack stroke, or hospitalization for congestive heart failure in the past 2 months

-Participant must not have been taking weight loss drugs including over-the-counter medications during the last 3 months

Where to Participate

187 locations are currently available of 194 planned
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